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During the formation of sperm, protamine binds to the phosphate backbone of DNA using the arginine-rich domain as an anchor. DNA is then folded into a toroid . Learn about indications, dosage and how it is supplied for the drug Protamine ( Protamines).Protamine Sulfate reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI).Medscape - Indication-specific dosing for (protamine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation . Protamine Sulfate Injection official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and . Indications for Protamine sulfate: Treatment of heparin overdose. Adult: Give by slow IV inj over 10 mins. Determine dose by coagulation studies; dose . Risk factors include high dose/overdose, rapid/previous administration, repeated doses, current/previous use of protamine-containing drugs (eg, NPH insulin, . Protamine Sulphate Injection BP 1% - Summary of Product Characteristics (SPC) by Amdipharm Mercury Company Limited.Protamine. ICU INDICATIONS: reversal of heparin. PRESENTATION AND ADMINISTRATION: IV: 50mg in 5ml (solution). Administer by slow IV injection over no .


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